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small molecule eif4e inhibitors  (eFFECTOR Therapeutics)

 
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    Structured Review

    eFFECTOR Therapeutics small molecule eif4e inhibitors
    Examples of reported inhibitors of m7GpppX cap binding to <t>eIF4E</t> and proposed acyclic nucleoside phosphonate prodrugs inspired by the anti-viral drugs, adefovir and tenofovir dipivoxil.
    Small Molecule Eif4e Inhibitors, supplied by eFFECTOR Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/small molecule eif4e inhibitors/product/eFFECTOR Therapeutics
    Average 90 stars, based on 1 article reviews
    small molecule eif4e inhibitors - by Bioz Stars, 2026-03
    90/100 stars

    Images

    1) Product Images from "Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer"

    Article Title: Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer

    Journal: Journal of medicinal chemistry

    doi: 10.1021/acs.jmedchem.3c00917

    Examples of reported inhibitors of m7GpppX cap binding to eIF4E and proposed acyclic nucleoside phosphonate prodrugs inspired by the anti-viral drugs, adefovir and tenofovir dipivoxil.
    Figure Legend Snippet: Examples of reported inhibitors of m7GpppX cap binding to eIF4E and proposed acyclic nucleoside phosphonate prodrugs inspired by the anti-viral drugs, adefovir and tenofovir dipivoxil.

    Techniques Used: Binding Assay

    eIF4E bound to 7n. The eIF4E protein backbone is shown as a gray ribbon with residues that interact with 7n shown as sticks. 7n is shown as sticks with cyan carbons. Nitrogen atoms are colored blue, oxygens in red and phosphorus in orange. Dashed lines represent hydrogen bonds (PDB: 8SX4).
    Figure Legend Snippet: eIF4E bound to 7n. The eIF4E protein backbone is shown as a gray ribbon with residues that interact with 7n shown as sticks. 7n is shown as sticks with cyan carbons. Nitrogen atoms are colored blue, oxygens in red and phosphorus in orange. Dashed lines represent hydrogen bonds (PDB: 8SX4).

    Techniques Used:

    Activation of eIF4E and cap-dependent translation.
    Figure Legend Snippet: Activation of eIF4E and cap-dependent translation.

    Techniques Used: Activation Assay



    Similar Products

    small molecule eif4e inhibitors  (eFFECTOR Therapeutics)
    90
    eFFECTOR Therapeutics small molecule eif4e inhibitors
    Examples of reported inhibitors of m7GpppX cap binding to <t>eIF4E</t> and proposed acyclic nucleoside phosphonate prodrugs inspired by the anti-viral drugs, adefovir and tenofovir dipivoxil.
    Small Molecule Eif4e Inhibitors, supplied by eFFECTOR Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/small molecule eif4e inhibitors/product/eFFECTOR Therapeutics
    Average 90 stars, based on 1 article reviews
    small molecule eif4e inhibitors - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Examples of reported inhibitors of m7GpppX cap binding to eIF4E and proposed acyclic nucleoside phosphonate prodrugs inspired by the anti-viral drugs, adefovir and tenofovir dipivoxil.

    Journal: Journal of medicinal chemistry

    Article Title: Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer

    doi: 10.1021/acs.jmedchem.3c00917

    Figure Lengend Snippet: Examples of reported inhibitors of m7GpppX cap binding to eIF4E and proposed acyclic nucleoside phosphonate prodrugs inspired by the anti-viral drugs, adefovir and tenofovir dipivoxil.

    Article Snippet: These compounds, in addition to recently reported small molecule eIF4E inhibitors reported by eFFECTOR Therapeutics, 40 will provide important tools for validating eIF4E as an anti-cancer therapeutic target, as well as provide new insights into the role of cap-dependent translation in cancer and other relevant human diseases.

    Techniques: Binding Assay

    eIF4E bound to 7n. The eIF4E protein backbone is shown as a gray ribbon with residues that interact with 7n shown as sticks. 7n is shown as sticks with cyan carbons. Nitrogen atoms are colored blue, oxygens in red and phosphorus in orange. Dashed lines represent hydrogen bonds (PDB: 8SX4).

    Journal: Journal of medicinal chemistry

    Article Title: Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer

    doi: 10.1021/acs.jmedchem.3c00917

    Figure Lengend Snippet: eIF4E bound to 7n. The eIF4E protein backbone is shown as a gray ribbon with residues that interact with 7n shown as sticks. 7n is shown as sticks with cyan carbons. Nitrogen atoms are colored blue, oxygens in red and phosphorus in orange. Dashed lines represent hydrogen bonds (PDB: 8SX4).

    Article Snippet: These compounds, in addition to recently reported small molecule eIF4E inhibitors reported by eFFECTOR Therapeutics, 40 will provide important tools for validating eIF4E as an anti-cancer therapeutic target, as well as provide new insights into the role of cap-dependent translation in cancer and other relevant human diseases.

    Techniques:

    Activation of eIF4E and cap-dependent translation.

    Journal: Journal of medicinal chemistry

    Article Title: Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer

    doi: 10.1021/acs.jmedchem.3c00917

    Figure Lengend Snippet: Activation of eIF4E and cap-dependent translation.

    Article Snippet: These compounds, in addition to recently reported small molecule eIF4E inhibitors reported by eFFECTOR Therapeutics, 40 will provide important tools for validating eIF4E as an anti-cancer therapeutic target, as well as provide new insights into the role of cap-dependent translation in cancer and other relevant human diseases.

    Techniques: Activation Assay